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Research is concentrated into following fields of medical physics: - Development of a method for determining optimal radiation treatments plans using biological models and quantitative criteria for the effectiveness of treatment of malignant neoplasms. "Clinical experience shows that the effectiveness of radiation therapy increases with increasing radiation dose in the tumor. At the same time, it is obvious that unsatisfactory results of radiation treatment are most often associated with the actual impossibility of bringing the required tumor dose to the tumor focus without causing significant damage to the surrounding healthy structures". The solution of this problem can be achieved by optimizing the irradiation plans on the basis of integral biological criteria for the effectiveness of radiation therapy.
- Evaluation of the "absorbed dose-survival effect of tumor cells" dependence on different concentrations of complementary chemotherapeutic drugs. The proposed project is devoted to theoretical and experimental research of the possibility of radiotherapy of malignant tumors using the approved clinical sources of photons (X-ray tubes) in the presence of complementary, including radiocontrast, agents in the tumor. The complementary agent is the particles of any chemical element with a high atomic number Z, for example, platinum, gold, gadolinium and other elements.
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