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Surface treatment for biocompatibility improvement by coatings formation. The development of principles and fundamentals of technology of biocompatible coatings deposition on the base of multi-level, functionally-gradient nanodimentional calcium-phosphate structures by plasma and ion-beam nanotechnological methods on the free surface of medical implants. The study of objective laws of biocompatible calcium-phosphate coating deposition on the surface of metals, alloys and ceramics of medical application by plasma of radio-frequency magnetron discharge, investigation their physicochemical, biochemical and biomedical properties. The possibility to use the biocomatible implants with different physicochemical characteristics of the surface as regulator of life cycle of stromal cells studied in cooperation with colleagues from Siberian State Medical University (Tomsk). The base characteristics of the calcium phosphate surface (morphology, elemental and phase composition, solubility) that promote the proliferation and differentiation of the stromal cells in osteogenous direction were determined. The rf-magnetron calcium-phosphate coating are capable significantly decrease of the substrate dissolution and extraction of alloying elements. The substrates with magnetron calcium-phosphate coating have good biocompatibility, show the absence of inflammation and infectious development while implantation to laboratory animals. Deposition of oxides and oxinitrid thin films for medical grafts by method of pulsed magnetron sputtering.
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